The Use of Radioactive Antiglobulin for the Detection of Erythrocyte Sensitization-Reference-Cited by-同舟云学术

The Use of Radioactive Antiglobulin for the Detection of Erythrocyte Sensitization

Published:1962-08-01 Issue:2 Volume:20 Page:214-232
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

COSTEA NICOLAS¹²,SCHWARTZ ROBERT¹³,CONSTANTOULAKIS MATTHEW¹⁴,DAMESHEK WILLIAM¹⁵

Affiliation:

1. Blood Research Laboratory, Pratt Clinic-New England Center Hospital, and the Department of Medicine, Tufts University School of Medicine, Boston, Mass.

2. Blood Research Laboratory, New England Center Hopital, (U.S.P.H.S. Fellowship #HPD-8986); Assistant in Medicine, Tufts University School of Medicine, Boston, Mass.

3. Blood Research Laboratory, New England Center Hospital; Assistant Professor of Medicine, Tufts University Medical School, Boston, Mass.

4. Blood Research Laboratory, New England Center Hospital, Boston, Mass. (Work done under tenure of Leukemia Foundation Fellowship.)

5. Tufts University School of Medicine; Director, Blood Research Laboratory, New England Center Hospital, Boston, Mass.

Abstract

Abstract Red cell sensitization by either agglutinating or incomplete antibodies was detected with an I131 labeled rabbit antihuman globulin serum (RAG). Nonspecific absorption of RAG by red cells was reduced to a minimum by the addition of 6 per cent bovine albumin. The reactions between RAG and the sensitized erythrocytes were typical of antigen-antibody reactions and the sensitivity of the test was found to be greater than the standard Coombs test. Quantitative studies of the degree of erythrocyte sensitization by isoimmune or autoimmune antibodies were possible with this technic.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/20/2/214/570785/214.pdf

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