Plasma Concentration of Chloramphenicol and Bone Marrow Suppression-Reference-Cited by-同舟云学术

Plasma Concentration of Chloramphenicol and Bone Marrow Suppression

Published:1963-03-01 Issue:3 Volume:21 Page:363-372
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

MCCURDY PAUL R.¹²,Gieschen Mona M.¹

Affiliation:

1. Department of Medicine, Georgetown University School of Medicine, and the Georgetown Medical Division, D. C. General Hospital, Washington, D. C.

2. Georgetown University School of Medicine, and Medical Officer, D. C. General Hospital, Washington, D. C.

Abstract

Abstract The appearance of reticulocytopenia and of vacuolated marrow blast cells has been correlated with elevated plasma levels and prolonged marrow exposure to free chloramphenicol. It is suggested that chloramphenicol may have produced bone marrow suppression in these patients in part by acting as an antimetabolic agent.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/21/3/363/570913/363.pdf

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4. Lack of evidence for systemic toxicity following topical chloramphenicol use;Eye;1998-09

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