Endoreduplication in Acute Leukemia-Reference-Cited by-同舟云学术

Endoreduplication in Acute Leukemia

Published:1963-02-01 Issue:2 Volume:21 Page:207-212
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

BOTTURA CÁSSIO¹²,FERRARI IRIS¹²

Affiliation:

1. Department of Clinical Medicine, Medical School of Ribeirão Prêto, Ribeirão Prêto, State of São Paulo, Brazil.

2. Department of Clinical Medicine, Medical School of Ribeirão Prêto, Ribeirão, Prêto State of São Paulo, Brazil.

Abstract

Abstract Chromosome studies were carried out on two occasions during the evolution of a case of acute myeloblastic leukemia. A normal karyotype was detected before treatment was started. A second analysis made while the patient was under treatment with 6-mercaptopurine showed a modal number of 44 chromosomes plus a small fragment. Apart from the abnormal karyotype, the leukemic cells showed a high incidence of endoreduplication and a cell with the feature of repeated endoreduplication was observed. The possible significance of these findings in acute leukemia is discussed.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/21/2/207/571066/207.pdf

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