The Identification and Synthesis of Activated Plasma Thromboplastin Component (PTC')-Reference-Cited by-同舟云学术

The Identification and Synthesis of Activated Plasma Thromboplastin Component (PTC')

Published:1963-12-01 Issue:6 Volume:22 Page:733-749
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

SCHIFFMAN SANDRA¹²,RAPAPORT SAMUEL I.¹³,PATCH MARY JANE¹⁴

Affiliation:

1. Departments of Medicine and Biochemistry, University of Southern California School of Medicine, Los Angeles, Calif.

2. University of Southern California School of Medicine, Los Angeles, Calif.

3. University of Southern California School of Medicine, and Chief, University of Southern California Hematology Service, Los Angeles County Hospital, Los Angeles, Calif.

4. Department of Medicine, University of Southern California School of Medicine, Los Angeles, Calif.

Abstract

Abstract 1. An activated form of PTC (PTC') which incorporates the properties of both native PTC and activated PTA (PTA') has been identified in BaSO4 eluates of intact citrated plasma. 2. PTC' has been synthesized from partially purified reagents in a reaction shown to require only PTA' and native PTC. Calcium ions greatly accelerate this reaction, but PTC' synthesis occurs slowly in their absence. 3. Kinetic and chromatographic analyses have shown that PTA' functions as an enzyme catalyzing the conversion of native PTC to PTC'. 4. On DEAE-cellulose chromatography, PTC and PTC' were found to elute at the same salt concentration.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/22/6/733/571358/733.pdf

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