The Effectiveness of Combinations of Antileukemic Agents in Inducing and Maintaining Remission in Children with Acute Leukemia-Reference-Cited by-同舟云学术

The Effectiveness of Combinations of Antileukemic Agents in Inducing and Maintaining Remission in Children with Acute Leukemia

Published:1965-11-01 Issue:5 Volume:26 Page:642-656
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

FREI EMIL¹,KARON MYRON²,LEVIN ROBERT H.³,FREIREICH EMIL J.¹,TAYLOR ROBERT J.²,HANANIAN JULIET⁴,SELAWRY OLEG⁴,HOLLAND JAMES F.⁴,HOOGSTRATEN BARTH⁵,WOLMAN IRVING J.⁶,ABIR ESSHAGH⁶,SAWITSKY ARTHUR⁷,LEE STANLEY⁷,MILLS STEPHAN D.⁸,BURGERT E. OMER⁸,SPURR CHARLES L.⁹,PATTERSON RICHARD B.⁹,EBAUGH FRANKLIN G.¹⁰,JAMES G. WATSON²,MOON JOHN H.¹¹

Affiliation:

1. Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Md. present address, University of Texas M. D. Anderson Hospital and Tumor Institute, Houstm, Texas.

2. Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, Md.

3. Deceased.

4. Department of Pediatrics and Medicine A, Roswell Park Memorial Institute, New York State Department of Health, Buffalo, N. Y. (CA-02599).

5. Mount Sinai Hospital, New York, N. Y. (CA-04457).

6. Children’s Hospital of Philadelphia, Philadelphia, Pa. (CA-4737).

7. Department of Medicine, Maimonides Hospital of Brooklyn, Brooklyn, New York (CA-05588).

8. Mayo Clinic, Rochester, Minnesota (CA-4646).

9. Bowman Gray School of Medicine, Winston-Salem, North Carolina (CA-03.927).

10. Hitchcock Hospital, Dartmouth Medical School, Hanover, New Hampshire (CA-04326).

11. Medical College of Virginia, Richmond, Virginia (CA-3735).

Abstract

Abstract 1. Combinations of effective agents produce at least an additive increase in complete remission rates over that which can be achieved when the agents are used individually. 2. Patients who do not achieve complete remission with initial treatment have a significantly shorter survival. 3. Alternating MTX and 6-MP at 28-day intervals during remission does not prolong the duration of remission over that of combined concurrent 6-MP and MTX. 4. The administration of folic acid antagonists intrathecally at 28-day intervals during antimetabolite maintained remission did not prolong the duration of remission. Meningeal leukemia, however, occurred significantly less frequently in these patients. 5. The duration of combined 6-MP and MTX maintained remission is not greater than that of 6-MP maintained remission. 6. The toxicity of 6-MP and MTX in combination in patients in remission is additive. The above conclusions were drawn from this comparative study of combinations of chemotherapeutic agents in children with acute lymphocytic leukemia.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/26/5/642/572478/642.pdf

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