The Persistence of Extramedullary Leukemic Infiltrates during Bone Marrow Remission of Acute Leukemia-Reference-Cited by-同舟云学术

The Persistence of Extramedullary Leukemic Infiltrates during Bone Marrow Remission of Acute Leukemia

Published:1965-08-01 Issue:2 Volume:26 Page:133-141
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

NIES BOYD A.¹²,BODEY GERALD P.¹³,THOMAS LOUIS B.¹³,BRECHER GEORGE¹⁴,FREIREICH EMIL J.¹⁵

Affiliation:

1. National Cancer Institute and Clinical Center, National Institutes of Health Bethesda, Md.

2. National Cancer Institute, National Institutes of Health, Bethesda, Md. Present address: Stanford University Hospital, Palo Alto, Calif.

3. National Cancer Institute, National Institutes of Health, Bethesda, Md.

4. Hematology Department, Clinical Center, National Institutes of Health, Bethesda, Md.

5. Medicine Branch, National Cancer Institute, National institutes of Health, Bethesda, Md.

Abstract

Abstract Leukemic cell infiltrates were found at autopsy in the tissues of 10 of 15 patients with acute leukemia dying during "complete bone marrow remission." The kidney was the most common site of leukemic cell infiltrates followed by the liver, testes, bowel, lung, central nervous system, and lymph nodes. These findings indicate that leukemic cells are not completely eradicated by current chemotherapy even in patients in whom no leukemic cells can be identified in the bone marrow. The distribution of residual leukemic cells demonstrates that the central nervous system is not the only reservoir of leukemic cells in patients during bone marrow remission.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/26/2/133/572126/133.pdf

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