Interaction of Hemoglobin Lepore with Sickle Cell Trait and Microcythemia (Thalassemia) in a Southern Italian Family-Reference-Cited by-同舟云学术

Interaction of Hemoglobin Lepore with Sickle Cell Trait and Microcythemia (Thalassemia) in a Southern Italian Family

Published:1965-04-01 Issue:4 Volume:25 Page:457-469
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

SILVESTRONI EZIO¹²,BIANCO IDA¹³,BAGLIONI CORRADO¹⁴

Affiliation:

1. Centro di Studi della Microcitemia e delle Anemie Microcitemiche, Istituto d’Igiene, Citta’ Universitaria, Rome, Italy and the International Laboratory of Genetics and Biophysics, Naples, Italy.

2. Division of Hematology, St. Eugene Hospital, Rome; Director of Research Center for Microcythemias, Department of Hygiene, University of Rome, Rome, Italy.

3. Research Center for Microncythemiac, Department of Hygiene, University of Rome, Rome, Italy.

4. International Laboratory of Genetics and Biophysics, Naples, Italy.

Abstract

Abstract An abnormal hemoglobin has been observed in a southern Italian family together with sickle cell hemoglobin and thalassemia (microcythemia). The hematologic study has shown that all the carriers of the abnormal hemoglobin are microcythemic. The hemoglobins of these individuals have been studied by paper, starch gel, starch block and agar gel electrophoresis. The abnormal hemoglobin has been isolated and identified by fingerprinting as Hb LeporeBoston. The combination of Hb LeporeBoston with thalassemia and sickle cell trait has been observed in members of this family. The hematologic and biochemical implications of the Hb Lepore/thalassemia disease are discussed.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/25/4/457/754280/457.pdf

Cited by 17 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Sickle cell haemoglobin and its interactions with other variant haemoglobins and with thalassaemias;Haemoglobinopathy Diagnosis;2020-02-28

2. Hb S/Hb Lepore with mild sickling symptoms: A hemoglobin variant with mostly δ-chain sequences ameliorates sickle-cell disease;American Journal of Hematology;1997-02

3. Hb Lepore (Pylos)/Hb S compounds heterozygosity in two Greek families;American Journal of Hematology;1995-06

4. Hemoglobin sickle-lepore: Report of two siblings and review of the literature;American Journal of Hematology;1993-11

5. Sickle Cell-Hb LeporeBoston Syndrome;American Journal of Diseases of Children;1982-01-01