Origin of Pulmonary Megakaryocytes

Author:

KAUFMAN RICHARD M.12,AIRO ROMANO13,POLLACK SIMEON12,CROSBY WILLIAM H.14,DOBERNECK RAYMOND15

Affiliation:

1. Departments of Hematology and Experimental Surgery, Walter Reed Army Institute of Research, Washington, D. C.

2. Department of Hematology, Walter Reed Army Institute of Research, Washington, D.C.

3. Department of Hematology, Walter Reed Army Institute of Research, Washington, D. C. Present address: Ospedale Cioile, Tortona, Italy.

4. Department of Hematology and Director, Division of Medicine, Waiter Reed Army institute of Research, Washington, D. C.

5. Department of Experimental Surgery, Walter Reed Army Institute of Research, Washington, D. C.

Abstract

Abstract 1. Evidence is presented which indicates that pulmonary megakaryocytes do not originate in the lungs but elsewhere in the body and are carried to the lungs in the venous blood. 2. Some megakaryocytes in the lungs evidently deliver platelets to the blood. 3. Surgery is a potent stimulus to megakaryocyte production; the numbers of megakaryocytes found in the lung postoperatively is significantly increased.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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