Experimental Production of Cold Agglutinins in Rabbits-Reference-Cited by-同舟云学术

Experimental Production of Cold Agglutinins in Rabbits

Published:1965-09-01 Issue:3 Volume:26 Page:323-340
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

COSTEA NICOLAS¹²,YAKULIS VINCENT¹³,HELLER PAUL¹⁴

Affiliation:

1. VA West Side Hospital and the University of Illinois College of Medicine, Chicago, Ill.

2. VA West Side Hospital; Assistant Professor of Medicine, University of Illinois College of Medicine, Chicago, Ill.

3. VA West Side Hospital, Chicago, Ill.

4. VA West Side Hospital; Professor of Medicine, University of Illinois College of Medicine, Chicago, Ill.

Abstract

Abstract The kinetics, serologic and immunochemical characteristics of cold agglutinins (CA) produced in rabbits by the intravenous injection of HKLM serotype 4b have been studied. The cold agglutinin was a γM-immunoglobulin. It agglutinated autologous, allogeneic and human erythrocytes at 4 C. In the presence of complement the CA was hemolytic in vitro and in vivo. The relevance of these observations to concepts of autoimmunity is discussed.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/26/3/323/572327/323.pdf

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