The Pelger-Huët Anomaly and Megaloblastic Anemia-Reference-Cited by-同舟云学术

The Pelger-Huët Anomaly and Megaloblastic Anemia

Published:1963-10-01 Issue:4 Volume:22 Page:472-476
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

ARDEMAN S.¹²,CHANARIN I.¹³,FRANKLAND A. W.¹

Affiliation:

1. Medical Research Council’s Experimental Haematology Research Unit, Department of Haematology and Wright-Fleming Institute of Microbiology, St. Mary’s Hospital Medical School, London, England.

2. Medical Research Council, London, England.

3. St. Mary's Hospital Medical School, London, England.

Abstract

Abstract A patient is described with addisonian pernicious anemia and with the Pelger-Huët anomaly of leukocytes. Before the patient was treated with vitamin B12, her peripheral blood contained three- and four-lobed neutrophils, but with therapy almost all the neutrophils showed the characteristic bilobed form of the Pelger-Huët anomaly. Before treatment the sex chromatin appendage was present in the neutrophils in normal numbers, but these could not be identified after treatment.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/22/4/472/571595/472.pdf

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