The Effect of Chloramphenicol in Human Bone-marrow Cultures-Reference-Cited by-同舟云学术

The Effect of Chloramphenicol in Human Bone-marrow Cultures

Published:1962-10-01 Issue:4 Volume:20 Page:424-431
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

VAS MAGDALENE R.¹²,BAIN BARBARA¹³,LOWENSTEIN LOUIS¹⁴

Affiliation:

1. Division of Haematology, Department of Medicine, Royal Victoria Hospital and McGill University Clinic, Montreal, Canada.

2. Department of Medicine, Royal Victoria Hospital, Montreal, Canada.

3. McGill University Clinic, Montreal, Canada.

4. Royal Victoria Hospital; Associate Professor of Medicine, McGill University, Montreal, Canada.

Abstract

Abstract 1. The effect of chloramphenicol on Fe uptake and Fe incorporation, using Fe59, was studied in human bone-marrow cultures. 2. Choramphenicol, in a concentration of 500 µg. per ml., resulted in a slight depression of uptake of iron by the erythroid cells and in a marked depression of the incorporation of iron into heme. 3. The results suggest that one toxic effect of chloramphenicol upon the bone marrow may involve direct interference with heme synthesis. 4. Under certain experimental conditions the inhibitory effect of chloramphenicol upon iron uptake and heme synthesis by the erythroblast is reversible.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/20/4/424/570833/424.pdf

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2. The Application of Tissue Culture to Drug and Toxicity Testing;Alternatives to Laboratory Animals;1979-12

3. The effect of chloramphenicol in intact erythroid cells;Journal of Molecular Biology;1966-11

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