Impairment of Red Cell Viability by Exposure to "Excess" Acid—Citrate Dextrose-Reference-Cited by-同舟云学术

Impairment of Red Cell Viability by Exposure to "Excess" Acid—Citrate Dextrose

Published:1966-10-01 Issue:4 Volume:28 Page:513-523
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

MAYER KLAUS¹²,LEY ALLYN B.¹³,D’AMARO JOSEPH¹⁴

Affiliation:

1. Cancer Anemia Section, Division of Clinical Investigation, Sloan-Kettering Institute for Cancer Research, and the Department of Medicine, Memorial and James Ewing Hospitals, New York, N. Y.

2. Henzatologist and Director of Blood Bank, Hospital for Special Surgery; Associate Director of Hematology and Blood Bank, Memorial Hospital for Cancer and Allied Diseases; Assistant Professor of Medicine, Cornell University Medical College, New York, N. Y.

3. Attending Physician, New York Hospital; Attending Physician, Memorial Hospital for Cancer and Allied Diseases; Chief of Anibulatory Service, New York Hospital; Professor of Medicine, Cornell University Medical College, New York, N. Y.

4. Sloan-Kettering institute for Cancer Research, New York, N. Y.

Abstract

Abstract Collection of blood in "excess" ACD leads to a loss of red cell viability when the blood is transfused back into the donor, even without any appreciable storage period. The mechanism of this loss of viability is not clear. The loss is accentuated by incubation at 37 C.; it is not affected by varying the dextrose concentration of the ACD; it cannot entirely be attributed to change in pH of the final suspension medium; and it is not related to the degree of swelling of the red cells. The loss of viability can completely be corrected by the addition of small amounts of chloride to the ACD. This effect is presumably the same as the "lesion of collection" described by Gibson et al. in relation to viability studies after 28 days of storage.4

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/28/4/513/754315/513.pdf

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4. Studies on the in vivo Elution of51Cr from Baboon Red Blood Cells;Vox Sanguinis;1981-05

5. Incompatibilityin vitroandin vivoDemonstrated Only with Saline-Suspended Red Cells;Vox Sanguinis;1979-05