B12 Dependence of Cell Uptake of Serum Folate: An Explanation for High Serum Folate and Cell Folate Depletion in B12 Deficiency-Reference-Cited by-同舟云学术

B12 Dependence of Cell Uptake of Serum Folate: An Explanation for High Serum Folate and Cell Folate Depletion in B12 Deficiency

Published:1973-03-01 Issue:3 Volume:41 Page:465-469
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Tisman Glenn¹²,Herbert Victor¹³

Affiliation:

1. Department of Pathology, Columbia University College of Physicians & Surgeons, New York, N. Y., and the Department of Medicine, Veterans Administration Hospital, Bronx, N. Y.

2. John Wesley Hospital, Los Angeles, Calif.

3. Columbia University, College of Physicians and Surgeons, New York City, N. Y. 10032; Medical Investigator, Veterans Administration Hospital, Bronx, N. Y. 10459.

Abstract

Abstract Bone marrow cells from patients with vitamin B12 deficiency took up much less N5-methyltetrahydrofolate(MeTHF) than did normal bone marrow cells but showed no significant reduction in pterolyglutamate (PGA) uptake. Addition of B12 to the incubation medium enhanced the cell uptake of MeTHF only in B12-deficient patients. These data support the concept of a B12 requirement for cell uptake of MeTHF.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/41/3/465/577673/465.pdf

Cited by 91 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Vitamin B<sub>12</sub> deficiency and Parkinson’s disease;Neurology, Neuropsychiatry, Psychosomatics;2023-07-04

2. Preparation and characterization of folate-enriched eggs and egg yolk powders;Journal of Agriculture and Food Research;2022-06

3. Vitamins and Infusion of Levodopa-Carbidopa Intestinal Gel;Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques;2021-04-20

4. Megaloblastic Anemia;Current Topics in Anemia;2018-02-07

5. Severe experimental folate deficiency in a human subject - a longitudinal investigation of red-cell folate immunoassay errors as megaloblastic anaemia develops;SpringerPlus;2014-09-23