Atypical Megakaryocytes in Preleukemic Phase of Acute Myeloid Leukemia

Author:

Smith W. Byron12,Ablin Arthur12,Goodman Joseph R.13,Brecher George14

Affiliation:

1. Departments of Pediatrics and Clinical Pathology and Laboratory Medicine, University of California San Francisco, San Francisco, Calif. 94122.!

2. Department of Pediatrics. University of California San Francisco, San Francisco, Calif. 94122.

3. University of California- San Francisco, San Francisco, Calif. 94122.

4. Department of Clinical Pathology and Laboratory Medicine. University of California San Francisco, San Francisco, Calif. 94122.

Abstract

Abstract Mono- and binucleated megakaryocytes appeared in the bone marrow of a 6-yr-old white male 9 mo prior to the development of acute myeloid leukemia; in addition, leukopenia and anemia antedated the diagnosis by 3½ and 9 mo, respectively. The report suggests that mono- and binucleated megakaryocytes may be a useful diagnostic finding in early leukemia.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Cited by 45 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Megakaryocytes in Pulmonary Blood Vessels;Acta Pathologica Microbiologica Scandinavica Section A Pathology;2009-08-15

2. Progression of Bone Marrow Abnormalities in Malignant Hemopoietic Dysplasia;Acta Medica Scandinavica;2009-04-24

3. Immunocytochemical detection of normal and abnormal megakaryocytes using monoclonal antibody to glycoprotein IIb-IIIa (TP80): The quantitative assay in normal and in leukaemic patients;Scandinavian Journal of Haematology;2009-04-24

4. Preleukaemic states in children;Scandinavian Journal of Haematology;2009-04-24

5. Zytologisch-zytochemische Methoden in der Klassifikation akuter Leukämien;DMW - Deutsche Medizinische Wochenschrift;2008-03-26

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