Macroglobulinemia in a Child With Acute Leukemia-Reference-Cited by-同舟云学术

Macroglobulinemia in a Child With Acute Leukemia

Published:1974-02-01 Issue:2 Volume:43 Page:191-199
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Čejka Jan¹²,Bollinger Robert O.¹³,Schuit Henrica R.E.¹⁴,Lusher Jeanne M.¹⁵,Chang Chung-Ho¹⁶,Zuelzer Wolf W.¹⁷

Affiliation:

1. Children’s Hospital of Michigan and The Child Research Center of Michigan, Detroit, Mich. 48201, and the Institute for Experimental Gerontology TNO, Rijswijk, The Netherlands.

2. Department of Immunochemistry, The Children's Hospital of Michigan, Detroit, Mich. 48201.

3. Department of Electron Microscopy, The Child Research Center of Michigan. Detroit, Mich. 48201.

4. Institute for Experimental Gerontology TNO, Rzjswijk (ZH), The Netherlands.

5. Wayne State University School of Medicine, Detroit, Mich. 48207; Associate Hematologist, The Children's Hospital of Michigan, Detroit, Mich. 48201.

6. The Children's Hospital of Michigan, Detroit, Mich. 48201.

7. Wayne State University School of Medicine, Detroit, Mich. 48207; Director of The Child Research Center of Michigan, Detroit. Mich. 48201; Chief of Laboratory Medicine, The Children's Hospital of Michigan. Detroit, Mich. 48201.

Abstract

Abstract A 12-yr-old boy with acute leukemia was found to have paraproteinemia and Bence-Jones proteinuria. The paraprotein was characterized as immunoglobulin M, type κ and the Bence Jones protein as free κ-chains. Increased amounts of β2-microglobulin were found in the patient’s serum and urine. Electron microscopic and immunofluorescence studies provided evidence of the presence of lymphoid leukemia cells apparently responsible for the production of the paraprotein.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/43/2/191/578001/191.pdf

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