Leukocyte Labeling With 51Chromium. III. The Kinetics of Normal Lymphocytes-Reference-Cited by-同舟云学术

Leukocyte Labeling With 51Chromium. III. The Kinetics of Normal Lymphocytes

Published:1972-08-01 Issue:2 Volume:40 Page:276-281
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Scott James L.¹²,Davidson J. Gary¹³,Marino Joseph V.¹³,McMillan Robert¹⁴

Affiliation:

1. Hematology Section, Medical Service, and Research Service, Wadsworth Veterans Administation Hospital, Los Angeles, Calif., and the Department of Medicine, UCLA School of Medicine, Los Angeles, Calif.

2. Hematology Section, Medical Service, Wadsworth Veterans Administration Hospital, Los Angeles, Calif., and Associate Professor of Medicine, Department of Medicine, UCLA School of Medicine, Los Angeles, Calif.

3. Wadsworth Veterans Administration Hospital, Los Angeles, Calif.

4. Veterans Administration Hospital, Los Angeles, Calif.

Abstract

Abstract The kinetics of radiochromate-labeled autologous blood lymphocytes were studied in normal subjects. The labeled cells equilibrated within hours with a recirculating lymphocyte pool (RLP) distributed between the blood, the spleen, and the bone marrow. The RLP was found to be about twice the size of the blood lymphocyte pool contained within it and turned over through the blood about 12 times daily. The labeled cells had an average half life in the RLP of 18 days.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/40/2/276/576964/276.pdf

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