Affiliation:
1. Sunnybrook Hospital and the Institute of Medical Science, University of Toronto, and the Ontario Cancer Institute, Toronto, Canada.
Abstract
Abstract
Utilizing an adherence separation procedure, marrow cells from six neutropenic patients were studied in cell culture for colony-forming ability (CFU-C), and for colony-stimulating function of the adherent cell (A-C) population. Assays on two patients showed reduced CFU-C and A-C function, while assays on three patients yielded normal CFU-C and A-C function; studies on the remaining patient exhibited reduced CFU-C in the presence of normal A-C function. The demonstration of these various abnormalities in marrow cell culture from neutropenic patients suggests that the in vitro techniques have relevance to the study of granulopoiesis in vivo.
Publisher
American Society of Hematology
Subject
Cell Biology,Hematology,Immunology,Biochemistry
Cited by
32 articles.
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