Abnormalities of Megakaryocytes in Sl/Sld Mice

Author:

Ebbe Shirley12,Phalen Elizabeth13,Stohlman Frederick14

Affiliation:

1. St. Elizabeth’s Hospital, Boston, Mass. 02135, and Tufts Medical School, Boston, Mass. 02111.

2. St. Elizabeth's Hospital, Boston, Mass. 02135; Associate Professor of Medicine, Tufts Medical School, Boston Mass. 02111.

3. St. Elizabeth's Hospital, Boston Mass. 02135.

4. St. Elizabeth's Hospital, Boston. Mass. 02135; Professor of Medicine, Tufts Medical School, Boston, Mass. 02111.

Abstract

Abstract Megakaryocytopoiesis was evaluated in Sl/Sld mice and their heterozygous and homozygous normal (+/+) littermates. Sl/Sld mice had a normal concentration of blood platelets which were of normal size. Numbers of megakaryocytes in bone marrow and spleen were reduced, but individual megakaryocytes were larger than normal.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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