Author:
Paglia DE,Valentine WN,Keitt AS,Brockway RA,Nakatani M
Abstract
Abstract
Erythrocytes from a patient with classical pyrimidine nucleotidase (PyN) deficiency had less than 10% residual PyN activity with uridine 5′-monophosphate (UMP) or cytidine 5′-monophosphate (CMP) as substrate, but exhibited brisk nucleotidase activity with thymidine 5′- monophosphate (dTMP). This strongly suggests the existence of separate enzymes or isozymes of PyN in normal human erythrocytes--an hypothesis that should be tested by similar studies in other cases of severe PyN deficiency, whether induced by genetic defects or lead toxicity.
Publisher
American Society of Hematology
Subject
Cell Biology,Hematology,Immunology,Biochemistry
Cited by
14 articles.
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