The Rhesus Antibody Anti-E in Pregnancy and Blood Transfusion

Author:

MALONE R. H.1,DUNSFORD I.1

Affiliation:

1. Blood Transfusion Centre, Sheffield, England.

Abstract

Abstract 1. Twelve cases of immunization by pregnancy or blood transfusion in which the Rhesus antibody anti-E was found, to the exclusion of anti-D or any other Rh antibody are reported. 2. Two hundred and fifty Rh antibodies were discovered in this laboratory during 1949 in 37,972 antenatal cases not previously tested, i.e., 1 in 152. Seven of these were pure anti-E, i.e., 2.8 per cent. This frequency is considerably higher than any previously reported. 3. All of the anti-E sera tested possessed to some degree, and 5 of them to a marked degree, the property of distinguishing cells with a double from those with a single dose of the antigen E. 4. The presence, in cells of various genotypes, of tine antigen D in association with the antigen E reduced their agglutinability with the same anti-E serum in such a manner as to suggest that the agglutinability of these cells depends upon the relative quantities of the E and D anitigens present. 5. By means of parallel titrations with a genotyping anti-E serum, against cells of known and unknown genotypes, it was possible to distinguish E/E from E/e cells in the presence or absence of associated D and, as a corollary, to distinguish D/D from D/d cells in the presence of associated E/E or E/e. 6. These results fit the hypothesis that the specific Rhesus antigens C, D and E are produced from a limited amount of "basic raw material" by the activity of the three genes: that the genes act independently and in competition and that the amount of each antigen produced is proportional to the dosage and "competitive value" of the corresponding gene.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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