Factor VIII/von Willebrand factor binding to von Willebrand's disease platelets

Author:

Gralnick HR,Williams SB,Shafer BC,Corash L

Abstract

Abstract A form of von Willebrand's disease has been described with enhanced ristocetin-induced platelet aggregation and anodal migration of the factor VIII/von Willebrand factor protein (type IIb). We studied two families with this form of von Willebrand's disease and macrothrombocytopenia. We have found that these platelets bind more of the normal and intermediate-sized multimers of the factor VIII/von Willebrand factor than normal platelets. Analysis of the binding data show an increased affinity of these vWd platelets for the factor VIII/von Willebrand factor. These findings are consistent with an increased number of platelet receptors, which, either by their native topography or migration on the platelet surface, bind factor VIII/von Willebrand factor protein with greater affinity than normal platelets, platelets of other vWd patients, and large platelets of other etiologies.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Cited by 11 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. The use of a growth factor inhibitor in the treatment of recurrent bleeding in von Willebrand disease;Russian journal of hematology and transfusiology;2023-12-28

2. Von Willebrand Factor Multimer Analysis and Classification: A Comprehensive Review and Updates;Seminars in Thrombosis and Hemostasis;2022-09-29

3. Obituary Harvey R. Gralnick, MD (1937–2020);Journal of Thrombosis and Haemostasis;2021-07-27

4. IN MEMORY OF ERIK JORPES;Scandinavian Journal of Haematology;2009-04-24

5. 8 Megakaryocytes and inherited thrombocytopenias;Baillière's Clinical Haematology;1997-02

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