Role of the intestinal mucosa in acute gastrointestinal GVHD-Reference-Cited by-同舟云学术

Role of the intestinal mucosa in acute gastrointestinal GVHD

Published:2016-12-02 Issue:1 Volume:2016 Page:119-127
ISSN:1520-4391
Container-title:Hematology
language:en
Short-container-title:

Author:

Peled Jonathan U.¹²,Hanash Alan M.¹,Jenq Robert R.¹²

Affiliation:

1. Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; and

2. Weill Cornell Medical College, New York, NY

Abstract

Abstract Intestinal graft-versus-host disease (GVHD) remains a significant obstacle to the success of allogeneic hematopoietic cell transplantation. The intestinal mucosa comprises the inner lining of the intestinal tract and maintains close proximity with commensal microbes that reside within the intestinal lumen. Recent advances have significantly improved our understanding of the interactions between the intestinal mucosa and the enteric microbiota. Changes in host mucosal tissue and commensals posttransplant have been actively investigated, and provocative insights into mucosal immunity and the enteric microbiota are now being translated into clinical trials of novel approaches for preventing and treating acute GVHD. In this review, we summarize recent findings related to aspects of the intestinal mucosa during acute GVHD.

Publisher

American Society of Hematology

Subject

Hematology

Link

http://ashpublications.org/hematology/article-pdf/2016/1/119/1251111/hem088372.pdf

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