Granulocyte colony-stimulating factor receptor mutations in a patient with acute lymphoblastic leukemia secondary to severe congenital neutropenia

Author:

Germeshausen Manuela1,Ballmaier Matthias1,Schulze Harald1,Welte Karl1,Flohr Thomas2,Beiske Klaus3,Storm-Mathisen Ingebjørg3,Abrahamsen Tore G.3

Affiliation:

1. Department of Pediatric Hematology and Oncology, Medical School Hannover, Germany

2. Institute of Human Genetics, University of Heidelberg, Germany

3. Departments of Pathology and Pediatrics, The National Hospital, Oslo, Norway

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference5 articles.

1. Myelodysplasia syndrome and acute myeloid leukemia in patients with congenital neutropenia receiving G-CSF therapy.;Freedman;Blood.,2000

2. G-CSF receptor mutations in patients with congenital neutropenia: frequency and implications in leukemic development [abstract].;Germeshausen;Blood.,1999

3. Clinical relevance of point mutations in the cytoplasmic domain of the granulocyte colony-stimulating factor receptor gene in patients with severe congenital neutropenia.;Tidow;Blood.,1997

4. Monosomy 7 and activating RAS mutations accompany malignant transformation in patients with congenital neutropenia.;Kalra;Blood.,1995

5. Rapid and reliable quantification of minimal residual disease in acute lymphoblastic leukemia using rearranged immunoglobulin and T-cell receptor loci by Lightcycler technology.;Nakao;Cancer Res.,2000

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