Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration-Reference-Cited by-同舟云学术

Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration

Published:2001-07-15 Issue:2 Volume:98 Page:428-435
ISSN:1528-0020
Container-title:Blood
language:en
Short-container-title:

Author:

Podar Klaus¹,Tai Yu-Tzu¹,Davies Faith E.¹,Lentzsch Suzanne¹,Sattler Martin¹,Hideshima Teru¹,Lin Boris K.¹,Gupta Deepak¹,Shima Yoshihito¹,Chauhan Dharminder¹,Mitsiades Constantine¹,Raje Noopur¹,Richardson Paul¹,Anderson Kenneth C.¹

Affiliation:

1. From the Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, and Department of Medicine, Harvard Medical School, Boston, MA.

Abstract

Multiple myeloma (MM) remains incurable, with a median survival of 3 to 4 years. This study shows direct effects of vascular endothelial growth factor (VEGF) upon MM and plasma cell leukemia (PCL) cells. The results indicate that VEGF triggers tumor cell proliferation via a protein kinase C (PKC)–independent Raf-1–MEK–extracellular signal-regulated protein kinase pathway, and migration via a PKC-dependent pathway. These observations provide the framework for novel therapeutic strategies targeting VEGF signaling cascades in MM.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/98/2/428/1675461/h8140100428.pdf

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