1. From the Centre for Developmental Cancer Therapeutics, Ludwig Institute for Cancer Research, Department of Haematology and Medical Oncology, Rotary Bone Marrow Research Laboratories, Royal Melbourne Hospital; Walter and Eliza Hall Institute for Medical Research; Department of Haematology and Medical Oncology, Western Hospital, Parkville, Victoria, Australia; Amgen Australia, Kew; and Amgen, Thousand Oaks, CA.