NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15)-Reference-Cited by-同舟云学术

NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15)

Published:2002-05-15 Issue:10 Volume:99 Page:3857-3860
ISSN:1528-0020
Container-title:Blood
language:en
Short-container-title:

Author:

Rosati Roberto¹,La Starza Roberta¹,Veronese Angelo¹,Aventin Ana¹,Schwienbacher Christine¹,Vallespi Teresa¹,Negrini Massimo¹,Martelli Massimo F.¹,Mecucci Cristina¹

Affiliation:

1. From the Hematology and Bone Marrow Transplantation Unit, University of Perugia; the International Cancer Center, Laboratory of Molecular Biology, Rovigo; the Department of Experimental and Diagnostic Medicine and Interdepartment Center for Cancer Research, University of Ferrara, Italy; the Department of Hematology, Sant Pau University Hospital, Barcelona; and the Department of Hematology, Vall d'Hebron Hospital, Barcelona, Spain.

Abstract

Fusion between the NUP98 and NSD3genes in a patient with acute myeloid leukemia associated with t(8;11)(p11.2;p15), is reported for the first time. The t(8;11)(p11.2;p15) was identified by classical cytogenetics. Fluorescence in situ hybridization (FISH) analysis revealed a split signal with a mix of BAC 118H17 and 290A12, indicating the translocation disrupted NUP98. FISH restriction at 8p11-12 showed a split of BAC 350N15. Molecular investigations into candidate genes in this BAC showed the NUP98 fusion partner at 8p11.2 was the NSD3 gene. To date the NSD3 gene has never been implicated in hematologic malignancies.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/99/10/3857/1684326/h81002003857.pdf

Reference23 articles.

1. NUP98 is fused to PMX1 homeobox gene in human acute myelogenous leukemia with chromosome translocation t(1;11)(q23;p15).;Nakamura;Blood.,1999

2. NUP98-HOXD13 gene fusion in therapy-related acute myelogenous leukemia.;Raza-Egilmez;Cancer Res.,1998

3. A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia.;Jaju;Blood.,2001

4. The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9.;Borrow;Nat Genet.,1996

5. Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia.;Nakamura;Nat Genet.,1996

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