A splice variant of human ephrin-A4 encodes a soluble molecule that is secreted by activated human B lymphocytes-Reference-Cited by-同舟云学术

A splice variant of human ephrin-A4 encodes a soluble molecule that is secreted by activated human B lymphocytes

Published:2000-01-01 Issue:1 Volume:95 Page:221-230
ISSN:1528-0020
Container-title:Blood
language:en
Short-container-title:

Author:

Aasheim Hans-Christian¹,Munthe Else¹,Funderud Steinar¹,Smeland Erlend B.¹,Beiske Klaus¹,Logtenberg Ton¹

Affiliation:

1. From the Departments of Immunology and Pathology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway, and the Department of Immunology, University Hospital Utrecht, Utrecht, The Netherlands.

Abstract

Abstract Ephrin-A4 is a ligand for the erythropoietin-producing hepatocellular (Eph) receptor family of tyrosine kinases. We have identified a secreted form of ephrin-A4, denoted ephrin-A4 (s), which is encoded by an alternatively spliced mRNA and is produced by in vivo activated B cells in tonsils. Blood B cells secrete ephrin-A4 (s) upon stimulation via the B-cell antigen receptor. A subpopulation of tonsil cells in the crypts with a dendritic cell phenotype was shown to express EphA2, an Eph receptor tyrosine kinase that was found to be capable of binding an ephrin-A4 immunoglobulin chimeric protein. We conclude that ephrin-A4 (s) may play a role in the interaction between activated B lymphocytes and dendritic cells in human tonsils. (Blood. 2000;95:221-230)

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/95/1/221/1659636/221.pdf

Reference46 articles.

1. Human B lymphocytes: phenotype, proliferation, and differentiation.;Banchereau;Adv Immunol.,1992

2. Gene rearrangement and B-cell development.;Chen;Curr Opin Immunol.,1993

3. Regulation of gene expression at early stages of B cell differentiation.;Hagman;Curr Opin Immunol.,1994

4. B lymphopoiesis: global factors, local control.;Kincade;Proc Natl Acad Sci USA.,1994

5. Germinal center development.;Liu;Immunol Rev.,1997

Cited by 55 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. EPH/Ephrin Signaling in Normal Hematopoiesis and Hematologic Malignancies: Deciphering Their Intricate Role and Unraveling Possible New Therapeutic Targets;Cancers;2023-08-04

2. Interference of EFNA4 suppresses cell proliferation, invasion and angiogenesis in hepatocellular carcinoma by downregulating PYGO2;Cancer Biology & Therapy;2022-11-20

3. EFNA4 promotes cell proliferation and tumor metastasis in hepatocellular carcinoma through a PIK3R2/GSK3β/β-catenin positive feedback loop;Molecular Therapy - Nucleic Acids;2021-09

4. IL-26 mediates epidermal growth factor receptor-tyrosine kinase inhibitor resistance through endoplasmic reticulum stress signaling pathway in triple-negative breast cancer cells;Cell Death & Disease;2021-05-21

5. Emerging Roles for Eph Receptors and Ephrin Ligands in Immunity;Frontiers in Immunology;2019-07-04