Identification and characterization of a bipotent (erythroid and megakaryocytic) cell precursor from the spleen of phenylhydrazine-treated mice-Reference-Cited by-同舟云学术

Identification and characterization of a bipotent (erythroid and megakaryocytic) cell precursor from the spleen of phenylhydrazine-treated mice

Published:2000-04-15 Issue:8 Volume:95 Page:2559-2568
ISSN:1528-0020
Container-title:Blood
language:en
Short-container-title:

Author:

Vannucchi Alessandro Maria¹,Paoletti Francesco¹,Linari Silvia¹,Cellai Cristina¹,Caporale Roberto¹,Ferrini Pierluigi Rossi¹,Sanchez Massimo¹,Migliaccio Giovanni¹,Migliaccio Anna Rita¹

Affiliation:

1. From the Division of Hematology, University of Florence and Azienda Ospedaliera Careggi, Florence, Italy; and the Laboratory of Cell Biology and Laboratory of Clinical Biochemistry, Istituto Superiore di Sanità, Rome, Italy.

Abstract

Abstract We have identified a cell population expressing erythroid (TER-119) and megakaryocyte (4A5) markers in the bone marrow of normal mice. This population is present at high frequency in the marrows and in the spleens involved in the erythroid expansion that occurs in mice recovering from phenylhydrazine (PHZ)-induced hemolytic anemia. TER-119+/4A5+ cells were isolated from the spleen of PHZ-treated animals and were found to be blast-like benzidine-negative cells that generate erythroid and megakaryocytic cells within 24-48 hours of culture in the presence of erythropoietin (EPO) or thrombopoietin (TPO). TER-119+/4A5+ cells represent a late bipotent erythroid and megakaryocytic cell precursors that may exert an important role in the recovery from PHZ-induced anemia.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/95/8/2559/1663756/2559.pdf

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