Murine hematopoietic stem cell characterization and its regulation in BM transplantation-Reference-Cited by-同舟云学术

Murine hematopoietic stem cell characterization and its regulation in BM transplantation

Published:2000-11-01 Issue:9 Volume:96 Page:3016-3022
ISSN:1528-0020
Container-title:Blood
language:en
Short-container-title:

Author:

Zhao Yi¹,Lin Yuanguang¹,Zhan Yuxia¹,Yang Gengjie¹,Louie Jeffrey¹,Harrison David E.¹,Anderson W. French¹

Affiliation:

1. From Gene Therapy Laboratories, Norris Cancer Center, University of Southern California (USC) Keck School of Medicine, Los Angeles, CA; the Division of Hematology, Department of Medicine, USC Keck School of Medicine, Los Angeles, CA; USC Flow Cytometry Laboratory, Department of Pathology, USC Keck School of Medicine, Los Angeles, CA; and Jackson Laboratory, Bar Harbor, ME.

Abstract

Abstract Using 5-color fluorescence-activated cell sorting, we isolated a subset of murine pluripotent hematopoietic stem cells (PHSC) with the phenotype Lin− Sca+ kit+CD38+ CD34− that appears to fulfill the criteria for most primitive PHSC. In the presence of whole bone marrow (BM) competitor cells, these cells produced reconstitution in lethally irradiated primary, secondary, and tertiary murine transplant recipients over the long term. However, these cells alone could not produce reconstitution in lethally irradiated recipients. Rapid proliferation of these cells after BM transplantation required the assistance of another BM cell subset, which has the phenotype Lin− Sca+ kit+ CD38−CD34+.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/96/9/3016/1668946/h8210003016.pdf

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