Treatment of chronic myelogenous leukemia with the tyrosine kinase inhibitor STI571 results in marked regression of bone marrow fibrosis

Author:

Beham-Schmid Christine1,Apfelbeck Ute1,Sill Heinz1,Tsybrovsky Oleksiy1,Höfler Gerald1,Haas Oskar A.1,Linkesch Werner1

Affiliation:

1. From the Institute of Pathology and the Division of Hematology, Department of Medicine, Karl-Franzens University, Graz, Austria; and the Children's Cancer Research Institute, St Anna Children's Hospital, Vienna, Austria.

Abstract

Morphologic bone marrow changes in patients with BCR-ABL–positive chronic myelogenous leukemia (CML) were investigated during treatment with the tyrosine kinase inhibitor STI571. Bone marrow trephine biopsy specimens from 23 pretreated patients with CML were examined morphologically and by morphometry before and 6 weeks and 3 months after the initiation of STI571 therapy (Glivec, Novartis, Basel, Switzerland). Bone marrow changes during treatment showed a quantitative normalization of erythropoiesis, a marked reduction of granulopoiesis, and a significant decrease in megakaryocytes with the reappearance of normal-sized forms. Furthermore, a significant regression of bone marrow fibrosis was observed in patients with initial fibrosis (P < .000 000 001). These results may expand the profile of STI571 and may offer novel therapeutic possibilities in diseases with bone marrow fibrosis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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