The snake venom toxin alboaggregin-A activates glycoprotein VI-Reference-Cited by-同舟云学术

The snake venom toxin alboaggregin-A activates glycoprotein VI

Published:2001-06-15 Issue:12 Volume:97 Page:3989-3991
ISSN:1528-0020
Container-title:Blood
language:en
Short-container-title:

Author:

Asazuma Naoki¹,Marshall Stuart J.¹,Berlanga Oscar¹,Snell Daniel¹,Poole Alastair W.¹,Berndt Michael C.¹,Andrews Robert K.¹,Watson Steve P.¹

Affiliation:

1. From the Department of Pharmacology, University of Oxford, and the Department of Pharmacology, University of Bristol, School of Medical Sciences, United Kingdom; and the Baker Medical Research Institute, Melbourne, Australia.

Abstract

The glycoprotein (GP)–Ib-IX-V receptor complex has recently been reported to signal through a pathway similar to that used by the collagen receptor GPVI, with a critical role described for the Fc receptor γ-chain. The evidence for this was based in part on studies with the GPIbα-selective snake venom toxin, alboaggregin-A. In the present study, it is reported that alboaggregin-A has activity at the collagen receptor GPVI in addition to GPIbα, and evidence is provided that this contributes to protein tyrosine phosphorylation, shape change, and GPIIb-IIIa–dependent aggregation. This may explain why responses to alboaggregin-A are distinct from those to von Willebrand factor– ristocetin.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/97/12/3989/1675203/h8120103989.pdf

Reference19 articles.

1. Echicetin: a snake venom protein that inhibits binding of von Willebrand factor and alboaggregins to platelet glycoprotein Ib.;Peng;Blood.,1993

2. Snake venom proteins modulating the interaction between von Willebrand factor and platelet glycoprotein Ib.;Fujimura;Thromb Haemost.,1996

3. Binding of a novel 50-kilodalton alboaggregin from Trimeresurus albolabris and related viper venom proteins to the platelet membrane glycoprotein Ib-IX-V complex: effect on platelet aggregation and glycoprotein Ib-mediated platelet activation.;Andrews;Biochemistry.,1996

4. Alboaggregins A and B: structure and interaction with human platelets.;Kowalska;Thromb Haemost.,1998

5. Glycoprotein Ib-V-IX, a receptor for von Willebrand factor, couples physically and functionally to the Fc receptor gamma-chain, Fyn, and Lyn to activate human platelets.;Falati;Blood.,1999

Cited by 24 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Structure-function relationship of the platelet glycoprotein VI (GPVI) receptor: does it matter if it is a dimer or monomer?;Platelets;2021-02-26

2. Platelets and Hemostasis;Comprehensive Toxicology;2018

3. Comparison of green pit viper and Agkistrodon halys antivenom in inhibition of coagulopathy due to Trimeresurus albolabris venom: an in-vitro study using human plasma;Hong Kong Medical Journal;2016-12-02

4. Unveiling the complexities of Daboia russelii venom, a medically important snake of India, by tandem mass spectrometry;Toxicon;2015-12

5. A critical role for the regulation of Syk from agglutination to aggregation in human platelets;Biochemical and Biophysical Research Communications;2014-01