Acquisition of intact allogeneic human leukocyte antigen molecules by human dendritic cells

Author:

Russo Vincenzo1,Zhou Dan1,Sartirana Claudia1,Rovere Patrizia1,Villa Antonello1,Rossini Silvano1,Traversari Catia1,Bordignon Claudio1

Affiliation:

1. From the HSR-Telethon Institute of Gene Therapy (TIGET) and the Cancer Immunotherapy and Gene Therapy Program, H.S. Raffaele Scientific Institute, Milan, Italy, and the Microscopy and Image Analysis, HSR, and Faculty of Medicine, the University of Milan Bicocca, Milan, Italy, and Gen Era S.P.A.

Abstract

Abstract In an attempt to transduce monocyte-derived dendritic cells (DCs) by a retroviral vector coding for a cell surface marker, we were confronted by the observation of high transfer of the surface molecule in the absence of vector proviral DNA in the treated cells. Indeed, DCs acquired the surface marker by a mechanism independent of the vector machinery, requiring cell-to-cell contact and involving transfer of lipids and a variety of intact membrane proteins. Most important, this property of DCs also includes acquisition of foreign human leukocyte antigen (HLA) molecules. Consequently, DCs become immunological hybrids as they display their own and foreign HLA molecules. The newly acquired HLA is fully functional because it allows recognition by allo-specific T lymphocytes and the binding and presentation of antigen peptides.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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