High incidence of Kaposi sarcoma–associated herpesvirus–related non-Hodgkin lymphoma in patients with HIV infection and multicentric Castleman disease

Author:

Oksenhendler Eric1,Boulanger Emmanuelle1,Galicier Lionel1,Du Ming-Qing1,Dupin Nicolas1,Diss Tim C.1,Hamoudi Rifat1,Daniel Marie-Thérèse1,Agbalika Félix1,Boshoff Chris1,Clauvel Jean-Pierre1,Isaacson Peter G.1,Meignin Véronique1

Affiliation:

1. From the Department of Immunology and Hematology, Laboratory of Hematology, Laboratory of Virology, CRC Viral Oncology Group, Department of Pathology, Hôpital Saint-Louis and the Department of Dermatology, NADER, Hôpital Tarnier-Cochin, Paris, France; the Department of Histopathology, Royal Free and University College Medical School, and The Wolfson Institute for Biomedical Research, University College London, London, United Kingdom.

Abstract

Multicentric Castleman disease (MCD) is a distinct type of lymphoproliferative disorder associated with inflammatory symptoms and interleukin 6 (IL-6) dysregulation. In the context of human immunodeficiency virus (HIV) infection, MCD is associated with Kaposi sarcoma–associated herpesvirus, also called human herpesvirus type 8 (KSHV/HHV8). Within a prospective cohort study on 60 HIV-infected patients with MCD, and a median follow-up period of 20 months, 14 patients developed KSHV/HHV8-associated non-Hodgkin lymphoma (NHL): 3 “classic” KSHV/HHV8+ Epstein-Barr virus–positive (EBV+) primary effusion lymphoma (PEL), 5 KSHV/HHV8+ EBV− visceral large cell NHL with a PEL-like phenotype, and 6 plasmablastic lymphoma/leukemia (3/3 KSHV/HHV8+ EBV−). The NHL incidence observed in this cohort study (101/1000 patient-years) is about 15-fold what is expected in the general HIV+ population. MCD-associated KSHV/HHV8+ NHL fell into 2 groups, suggesting different pathogenesis. The plasmablastic NHL likely represents the expansion of plasmablastic microlymphoma from the MCD lesion and progression toward aggressive NHL. In contrast, the PEL and PEL-like NHL may implicate a different original infected cell whose growth is promoted by the cytokine-rich environment of the MCD lesions.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference36 articles.

1. Kaposi's sarcoma-associated herpesvirus.;Boshoff;Cancer Surveys: Infections and Human Cancer.,1999

2. Transient angiolymphoid hyperplasia and Kaposi's sarcoma after primary infection with human herpesvirus 8 in a patient with human immunodeficiency virus infection.;Oksenhendler;N Engl J Med.,1999

3. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body cavity-based lymphomas.;Cesarman;N Engl J Med.,1995

4. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease.;Soulier;Blood.,1995

5. Multicentric Castleman's disease.;Peterson;Semin Oncol.,1993

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3