Heavy Chain Disease of the µ (γM) Type: Report of the First Case-Reference-Cited by-同舟云学术

Heavy Chain Disease of the µ (γM) Type: Report of the First Case

Published:1970-08-01 Issue:2 Volume:36 Page:137-144
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

FORTE FRANK A.¹²,PRELLI FRANCES¹³,YOUNT WILLIAM J.¹⁴,JERRY L. MARTIN¹⁴,KOCHWA SHAUL¹⁵,FRANKLIN EDWARD C.¹⁶,KUNKEL HENRY G.¹⁴

Affiliation:

1. Mount Sinai School of Medicine, New York, N.Y., New York University School of Medicine, New York, N.Y., and The Rockefeller University, New York, N.Y.

2. Department of Medicine (Hematology), Mount Sinai School of Medicine, New lark, N.Y.

3. New York University School of Methcine, New York, N.Y.

4. The Rockefeller University, New York, N.Y.

5. Mount Sinai School of Medicine, New York, N.Y.

6. New York University School of Medicine, New York, N.Y.

Abstract

Abstract The serum of a patient with chronic lymphocytic leukemia, and amyloidosis, was found to contain an unusual protein with µ chain antigenic determinants. It was devoid of light chains and was present in the form of multiple disulfide linked polymers. The patient also had a kappa Bence Jones protein in the serum and urine. The possibility is raised that the heavy chain lacks a portion of the chain necessary for coupling with light chains.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/36/2/137/575703/137.pdf

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