Colony-stimulating Factor and Inhibitor Levels in Acute Granulocytic Leukemia-Reference-Cited by-同舟云学术

Colony-stimulating Factor and Inhibitor Levels in Acute Granulocytic Leukemia

Published:1971-08-01 Issue:2 Volume:38 Page:143-152
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

METCALF DONALD¹²,CHAN SOH HA¹³,GUNZ FREDERICK W.¹⁴,VINCENT PAUL¹⁴,RAVICH ROBERT B. M.¹⁴

Affiliation:

1. Cancer Research Unit, Walter and Eliza Hall Institute, Royal Melbourne Hospital, Melbourne, Australia, and Kanematsu Memorial Institute, Sydney Hospital, Sydney, Australia.

2. Cancer Research Unit, Walter and Eliza Hall Institute, Royal Melbourne hospital, Melbourne, Australia.

3. Walter and Eliza Hall institute, Royal Melbourne Hospital, Melbourne, Australia.

4. Kanematsu Memorial Institute, Sydney Hospital, Sydney, Australia.

Abstract

Abstract Assays were performed on bone marrow colony-stimulating-factor (CSF) levels in the serum and urine of 33 patients with acute granulocytic and myelomonocytic leukemia. Of 251 serum samples, 30% showed elevated CSF levels as did 53% of 1422 urines tested. Levels of serum inhibitors of colony formation were abnormally low or undetectable in 57% of sera from leukemic patients. Patients in relapse were unable to respond to infections by developing high serum CSF levels and low serum-inhibitor levels were more common in patients with a short survival time and in some types of patient during relapses.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/38/2/143/576098/143.pdf

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