Correlation Between Various Blood White Cell Pools and the Serum B12-binding Capacities-Reference-Cited by-同舟云学术

Correlation Between Various Blood White Cell Pools and the Serum B12-binding Capacities

Published:1971-02-01 Issue:2 Volume:37 Page:142-151
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

CHIKKAPPA G.¹²,CORCINO J.¹³,GREENBERG M. L.¹⁴,HERBERT V.¹⁵

Affiliation:

1. Department of Medicine and Division of Hematology, The Mount Sinai Hospital and Mount Sinai School of Medicine of the City University of New York, New York, N. Y.

2. Mount Sinai School of Medicine, New York, N. Y.

3. Mount Sinai School of Medicine, New York, N. Y.; holder of USPHS Senior Postdoctoral Fellowship AM39795.

4. Mount Sinai School of Medicine, New York, N. Y.; Scholar of tile Leukemia Society of America.

5. College of Physicians and Surgeons, Columbia University, New York, N. Y.; formerly Professor of Medicine, Mount Sinai School of Medicine, New York, N. Y.; holder of Health Research Council of tile City of New York Career Scientist Award 1-435 and a Veterans Administration Medical Investigatorship.

Abstract

Abstract Twenty-four patients with various hematologic and nonhematologic diseases were studied to correlate the various fractions of the serum B12-binding capacity with the blood granulocyte and leukocyte pools and granulocyte turnover rates. The total blood granulocyte pools correlated well with the serum unsaturated B12-binding capacity, especially with the alpha fraction. At least part of the serum B12-binding protein appears to be derived from the neutrophil and from the eosinophil but little or none from the myeloblast. The serum unsaturated B12-binding capacity appears to be a simple index of the total blood granulocyte pool.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/37/2/142/575759/142.pdf

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