Polycythemia Vera with Ph1 Chromosomes in Two Brothers

Author:

LEVIN WILLIAM C.12,HOUSTON ELSIE W.12,RITZMANN STEPHAN E.13

Affiliation:

1. Department of Medicine, Hematology Research Laboratory and the Shriners Burns Institute, Division of Hematology, University of Texas Medical Branch, Galveston, Texas.

2. Divison of Hematology, University of Texas Medical Branch.

3. Division of Hematology, Shriners Burns Institute, University of Texas Medical Branch.

Abstract

Abstract Two brothers with polycythemia rubra vera have been studied: one before treatment and one after many years of treatment. Direct harvests of marrow aspirates from both patients exhibited the presence of the Ph1 chromosome. Moderately increased LAP levels were present in both. Available data do not indicate whether the disease and the chromosomal aberrations in these two brothers are familial or fortuitous.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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