Combination Chemotherapy in Lymphosarcoma and Reticulum Cell Sarcoma-Reference-Cited by-同舟云学术

Combination Chemotherapy in Lymphosarcoma and Reticulum Cell Sarcoma

Published:1969-02-01 Issue:2 Volume:33 Page:370-378
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

HOOGSTRATEN BARTH¹,OWENS ALBERT H.²,LENHARD RAYMOND E.²,GLIDEWELL OLIVER J.³,LEONE LOUIS A.⁴,OLSON KENNETH B.⁵,HARLEY JOHN B.⁶,TOWNSEND STUART R.⁷,MILLER SHERWOOD P.⁸,SPURR CHARLES L.⁹

Affiliation:

1. The Mount Sinai Hospital School of Medicine, 100 Street and Fifth Avenue, New York, N.Y. 10029 (CA-04457).

2. Johns Hopkins Hospital, Baltimore, Md. (CA-06973).

3. Associate Biostatistician, Roswell Park Memorial Institute, Buffalo, N.Y. (CA-02593).

4. Rhode Island Hospital, Providence, R.I. (CA-08025).

5. Albany Medical College of Union University, Albany, N.Y. (CA-06594).

6. West Virginia University Medical Center, Morgantown, W.Va. (CA-07757).

7. McGill University Hospitals, Montreal, Canada.

8. Maimonides Hospital, Brooklyn, N.Y. (CA-05588).

9. Bowman Gray School of Medicine, Winston-Salem, N.C. (CA-03927).

Abstract

Abstract Patients with lymphosarcoma and reticulum cell sarcoma were randomly allocated to treatment with cyclophosphamide alone or to two dosage levels of combinations of cyclophosphamide, vincristine and prednisone. Remission induction was significantly better for the combinations with lymphosarcoma patients and for the high dose combination with reticulum cell sarcoma patients. Toxicity, more pronounced with high combination, was tolerable. Remissions as measured by decrease in tumor size were associated with improvement in hemoglobin, performance, food intake, weight and fever. The study provides impetus for further trial with other drug combinations and schedules.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/33/2/370/574972/370.pdf

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