Megakaryocyte Size in Thrombocytopenic and Normal Rats

Author:

EBBE SHIRLEY12,STOHLMAN FREDERICK13,OVERCASH JOAN14,DONOVAN JANET14,HOWARD DONALD14

Affiliation:

1. St. Elizabeth’s Hospital and Tufts University School of Medicine, Boston, Mass.

2. St. Elizabeth's Hospital, Assistant Professor of Medicine, Tufts Medical School.

3. St. Elizabeth's Hospital, Professor of Medicine, Tufts Medical School.

4. St. Elizabeth's Hospital.

Abstract

Abstract Thrombocytopenia was produced in rats by exchange transfusion with platelet-poor homologous blood or heterologous antiserum. The subsequent rapid rise in platelet counts to thrombocytotic levels suggested accelerated platelet production. During this recovery period macromegakaryocytes were present in the bone marrow. The findings suggested that thrombocytopenia affected megakaryocytopoiesis at the precursor cell level with resultant macrocytosis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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