2,3-Diphosphoglycerate Content and Oxygen Affinity as a Function of Red Cell Age in Normal Individuals-Reference-Cited by-同舟云学术

2,3-Diphosphoglycerate Content and Oxygen Affinity as a Function of Red Cell Age in Normal Individuals

Published:1971-10-01 Issue:4 Volume:38 Page:463-467
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

HAIDAS STAVROS¹²,LABIE DOMINIQUE¹³,KAPLAN JEAN-CLAUDE¹⁴

Affiliation:

1. l’Institut de Pathologie Moléculaire, Paris, France.

2. Service de Pédiatric, Clinique Universitaire, Hôpital Sainte-Sophie, Athens, Greece; Visiting Research Assistant, Institut National de la Santé de Recherche Médicale, Paris, France.

3. Institut National de la Santé de la Recherche Medicale, Institut de Pathologic Molécislaire, Paris, France.

4. Institut de Pathologic Moléculaire, Paris, France.

Abstract

Abstract A parallel decline of 2,3-diphosphoglycerate (2,3-DPG) and P50 of intracorpuscular hemoglobin is found in red blood cells during their in vivo aging. After 2,3-DPG depletion due to in vitro storage, the capacity to restore, 2,3-DPG in the presence of inosine is significantly impaired in senescent cells as compared with young cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/38/4/463/576512/463.pdf

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