Surface Immunoglobulins of Circulating Lymphocytes in Mouse Plasmacytoma. II. The Influence of Plasmacytoma RNA on Surface Immunoglobulins of Lymphocytes

Author:

Bhoopalam Nirmala12,Yakulis Vincent13,Costea Nicolas14,Heller Paul15

Affiliation:

1. Veterans Administration West Side Hospital and the Departments of Medicine, Biochemistry, and Microbiology, University of Illinois Abraham Lincoln School of Medicine, Chicago, Ill.

2. Veterans Administration West Side Hospital and University of Illinois Abraham Lincoln School of Medicine, Chicago, Ill.

3. Veterans Administration West Side Hospital, Chicago, Ill.

4. Division of Hematology, Cook County Hospital and Professor of Medicine, University of Illinois Abraham Lincoln School of Medicine, Chicago, Ill.

5. Veterans Administration West Side Hospital; and Chief, Hematology Section, Department of Medicine; and Professor of Medicine, University of Illinois Abraham Lincoln School of Medicine, Chicago, Ill.

Abstract

Abstract Circulating lymphocytes of plasmacytoma-carrying BALB/c mice were found to lose their normal surface immunoglobulins; in their place surface structures characteristic of the specific plasmacytoma globulin were demonstrated by the immunocytoadhesion technique. These changes were experimentally reproduced by the incubation of normal BALB/c lymphocytes with an RNA preparation obtained by hot phenol extraction from the excised plasmacytomas. RNA treated by RNAse was inactive, while DNAse or trypsin had no inactivating effect. Lymphocytes, killed with heat or KCN, underwent no alteration of surface receptors following incubation with the tumor RNA. Plasmacytoma RNA, injected intraperitoneally into normal mice, also altered the reactivity of circulating lymphocytes. These observations suggest the possibility that this effect contributes to the functional impairment of the immune system in this disease.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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