Treatment of Meningeal Leukemia With Pyrimethamine-Reference-Cited by-同舟云学术

Treatment of Meningeal Leukemia With Pyrimethamine

Published:1971-08-01 Issue:2 Volume:38 Page:131-137
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

GEILS GEORGE F.¹²,SCOTT CHARLIE W.¹³,BAUGH CHARLES M.¹⁴,BUTTERWORTH CHARLES E.¹³

Affiliation:

1. Division of Nutrition and Hematology, Department of Medicine, University of Alabama School of Medicine, Birmingham, Ala.

2. Division of Nutrition and Hematology, University of Alabama School of Medicine, Birmingham, Ala.; recipient of NIH Training Grant T 01-05526.

3. Division of Nutrition and Hematology, University of Alabama School of Medicine, Birmingham, Ala.

4. Department of Nutrition and Hematology, University of Alabama School of Medicine, Birmingham, Ala.

Abstract

Abstract Pyrimethamine, a substituted pyrimidine with potent folate antagonistic properties, was given orally to treat two episodes of meningeal leukemia in a longterm survivor with acute myeloblastic leukemia. Remissions of seven and at least 6 mo duration were obtained on the two occasions. Spinal fluid concentrations of pyrimethamine were 10-25% of the simultaneous plasma concentrations. Considerations regarding lipid solubility, body distribution, and easily reversible toxicity of pyrimethamine suggest that further therapeutic trials are warranted, especially in childhood lymphoblastic leukemia.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/38/2/131/576158/131.pdf

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