Colony Growth of Human Leukemic Peripheral Blood Cells In Vitro-Reference-Cited by-同舟云学术

Colony Growth of Human Leukemic Peripheral Blood Cells In Vitro

Published:1971-10-01 Issue:4 Volume:38 Page:500-508
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

ROBINSON WILLIAM A.¹²,KURNICK JOHN E.¹³,PIKE BEVERLEY L.¹⁴

Affiliation:

1. Department of Medicine, Division of Hematology, Section of Oncology, University of Colorado Medical Center, Denver, Colo.

2. Section of Oncology, Division of Hematology, University of Colorado Medical Center, Denver, Colo.

3. Hematology Trainee, USPHS 94757, presently Department of Medicine, Fitzsimons General Hospital, Denver, Col.

4. University of Colorado Medical Center, Denver, Colo.

Abstract

Abstract The colony-forming potential of peripheral white blood cells from patients with acute leukemia on normal human peripheral WBC feeder layers has been studied. White blood cells from 12 of 20 patients with acute granulocytic leukemia gave rise to large numbers of colonies, while WBC from eight patients with AGL, four patients with acute lymphocytic leukemia and three patients with acute stem cell leukemia gave rise to no colonies or only small numbers. Colonies formed from WBC of patients with AGL appear to go through a process of morphologic maturation to segmented granulocyte forms. Leukemic WBC will not serve as feeder layers in this system, but are not inhibitory in this respect. The significance of these findings is discussed.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/38/4/500/576561/500.pdf

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