Granulocyte Chemotaxis in the Chediak-Higashi Syndrome of Mink-Reference-Cited by-同舟云学术

Granulocyte Chemotaxis in the Chediak-Higashi Syndrome of Mink

Published:1972-05-01 Issue:5 Volume:39 Page:644-649
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Clark Robert A.¹²,Kimball Harry A.¹³,Padgett George A.¹⁴

Affiliation:

1. Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md., and Department of Veterinary Pathology, College of Veterinary Medicine, Washington State University, Pullman, Wash.

2. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.

3. Inflammatory Diseases Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.

4. Washington State University, Pullman, Wash.

Abstract

Abstract Studies of granulocyte chemotaxis were performed in mink with the Chediak-Higashi syndrome. In vivo migration of leukocytes to an inflammatory site was reduced in the affected animals. In vitro studies documented a consistent early impairment in the chemotactic response of Chediak-Higashi mink granulocytes. Serum from Chediak-Higashi mink generated normal amounts of chemotactic factors. The cellular defect in leukocyte chemotaxis in mink is comparable to that observed in humans with the Chediak-Higashi syndrome and may contribute to the increased susceptibility to infection in this disease.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/39/5/644/576847/644.pdf

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