A Neonate with Down’s Syndrome and Transient Abnormal Myelopoiesis: Serial Blood and Bone Marrow Studies

Author:

NAGAO TAKESHI12,LAMPKIN BEATRICE C.13,HUG GEORGE14

Affiliation:

1. Department of Pediatrics, University of Cincinnati, The Children’s Hospital, and The Children’s Hospital Research Foundation, Cincinnati, Ohio.

2. Division of Hematology, Department of Pediatrics, University of Tokyo, Japan; formerly Research Fellow, Division of Pediatric Hematology, Children's Hospital Research Foundation, Cincinnati, Ohio.

3. University of Cincinnati, Cincinnati, Ohio; recipient of Special Fellowship Award 1-F03-CA-42,380 from the National Cancer Institute.

4. University of Cincinnati, Cincinnati, Ohio.

Abstract

Abstract Observations were made of the blood and bone marrow of a male infant with Down’s syndrome during the first year of life. At 4 days of age there were 36,500 myeloblasts/cu.mm. in the blood and 10.8 per cent myeloblasts in the marrow. Initially it appeared the patient had acute myeloblastic leukemia. However, the clinical course and kinetic and electron microscopic studies of his bone marrow cell population indicate he did not have acute leukemia.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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