Hypothesis: Studies on Human Platelets III. A Contractile Protein Model for Platelet Aggregation

Author:

BOOYSE F. M.1,RAFELSON MAX E.12

Affiliation:

1. Department of Biochemistry, Presbyterian-St. Luke's Hospital and University of Illinois College of Medicine, Chicago, Illinois.

2. Department of Biochemistry, University of Illinois and John W. and Helen H. Watzek Memorial Chairman of Biochemistry, Presbyterian-St. Luke's Hospital, Chicago, Illinois.

Abstract

Abstract A new hypothesis is proposed for platelet aggregation. The model involves the formation of intermolecular platelet actomyosin bridges between platelet actin and platelet myosin moieties localized on or near the surface of adjacent platelets. These intermolecular platelet actomyosin bridges can then contract in the presence of ATP, drawing the platelets into a tight mass or thrombus.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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