Myelofibrosis in Chronic Granulocytic Leukemia-Reference-Cited by-同舟云学术

Myelofibrosis in Chronic Granulocytic Leukemia

Published:1971-02-01 Issue:2 Volume:37 Page:152-162
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

GRALNICK HARVEY R.¹²,HARBOR JOHN¹³,VOGEL CHARLES¹⁴

Affiliation:

1. Hematology Service and the Nuclear Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Md., and the Solid Tumor Service, Medicine Branch, National Cancer Institute, Bethesda, Md.

2. Clinical Center, National Institutes of Health, Bethesda, Md.

3. Dept, of Nuclear Medicine, Georgetown University, Washington, D.C.; formerly Nuclear Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Md.

4. Lymphoma Treatment, Kampola, Uganda; formerly Solid Tumor Service, Medicine Branch, National Cancer Institute, Bethesda, Md.

Abstract

Abstract In 181 patients with chronic granulocytic leukemia (CGL) 39 patients demonstrated myelofibrosis (MF) during the course of their disease. These groups can be divided into two groups: one group initially presenting with the clinical and laboratory findings of CGL but with concomitant MF and a second group in whom MF developed late in the course of CGL. The occurrence of MF with CGL was associated with three findings: (1) elevation of the leukocyte alkaline phosphatase, (2) a very poor prognosis and (3) the frequent association of MF and blastic transformation of CGL. MF should be considered an integral part of CGL and when present should be considered part of the terminal phase of CGL and treated accordingly.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/37/2/152/575781/152.pdf

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