Brief Report: Lipid Peroxidation in Aging Platelets

Author:

OKUMA MINORU12,STEINER MANFRED13,BALDINI MARIO14

Affiliation:

1. Division of Hematologic Research, The Memorial Hospital, Pawtucket, and Brown University, Providence, Rhode Island.

2. The Memorial Hospital, Pawtucket, RI.

3. Brown University, Providence, RI.; Associate Director, Divinon of Henzatologic Research, The Memorial Hospital, Pawtucket, RI.

4. Professor of Medicine (Clinical), Brown University, Providence, RI.; Hematologist-in-Chief and Director, Divi.rion of Heniatologic Research, The Memorial Hospital, Pawtucket, RI.

Abstract

Abstract Blood platelets showed an age dependent accumulation of lipid peroxides. Lipid peroxidation stimulated by heavy metal also increased with platelet age and rose at a much faster rate than the spontaneous peroxide formation. This suggests the loss of a cellular defense mechanism against lipid peroxidation in aging blood platelets.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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1. Biochemical Studies in Hermansky-Pudlak Syndrome;Scandinavian Journal of Haematology;2009-04-24

2. PLATELET AND FIBRINOGEN KINETIC EVALUATION OF THROMBOGENESIS;Scandinavian Journal of Haematology;2009-04-24

3. Chromium51 Uptake as A Function of Platelet Age;Scandinavian Journal of Haematology;2009-04-24

4. Radiation-induced volatile hydrocarbon production in platelets;Life Sciences;1989-01

5. Fractionation of platelets according to size: Functional and biochemical characteristics;American Journal of Hematology;1986-01

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