Reproducing the molecular subclassification of peripheral T-cell lymphoma–NOS by immunohistochemistry

Author:

Amador Catalina1ORCID,Greiner Timothy C.1ORCID,Heavican Tayla B.1,Smith Lynette M.2ORCID,Galvis Karen Tatiana13,Lone Waseem1,Bouska Alyssa1,D’Amore Francesco4ORCID,Pedersen Martin Bjerregaard4ORCID,Pileri Stefano56ORCID,Agostinelli Claudio6ORCID,Feldman Andrew L.7ORCID,Rosenwald Andreas89,Ott German1011,Mottok Anja1213,Savage Kerry J.12,de Leval Laurence14,Gaulard Philippe15,Lim Soon Thye16ORCID,Ong Choon Kiat16ORCID,Ondrejka Sarah L.17,Song Joo18,Campo Elias1920ORCID,Jaffe Elaine S.21ORCID,Staudt Louis M.22,Rimsza Lisa M.23,Vose Julie24ORCID,Weisenburger Dennis D.18,Chan Wing C.18,Iqbal Javeed1

Affiliation:

1. Department of Pathology and Microbiology and

2. Department of Biostatistics, University of Nebraska Medical Center, Omaha, NE;

3. Department of Pathology and Laboratory Medicine, Fundacion Santa Fe de Bogota University Hospital, Bogota, Colombia;

4. Department of Hematology, Aarhus University Hospital, Aarhus, Denmark;

5. European Institute of Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Milan, Italy;

6. Department of Specialized, Experimental and Diagnostic Medicine, University of Bologna, Bologna, Italy;

7. Department of Laboratory Medicine and Pathology, College of Medicine, Mayo Clinic, Rochester, MN;

8. Institute of Pathology and

9. Comprehensive Cancer Center Mainfranken, University of Würzburg, Würzburg, Germany;

10. Department of Clinical Pathology and

11. Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Robert-Bosch-Krankenhaus, Stuttgart, Germany;

12. Center for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, BC, Canada;

13. Institute of Human Genetics, Ulm University/University Medical Centre, Ulm, Germany;

14. Institute of Pathology, Lausanne University Hospital, Lausanne, Switzerland;

15. Département de Pathologie, Hôpital Henri-Mondor, Université Paris-Est, INSERM U955, Créteil, France;

16. Division of Medical Oncology, National Cancer Centre Singapore/Duke–National University of Singapore (NUS) Medical School, Singapore;

17. Department of Pathology, Cleveland Clinic, Cleveland, OH;

18. Department of Pathology, City of Hope National Medical Center, Duarte, CA;

19. Hematopathology Unit, Hospital Clinic, Barcelona, Spain;

20. Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain;

21. Laboratory of Pathology and

22. Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;

23. Department of Laboratory Medicine and Pathology, Mayo Clinic, Scottsdale, AZ; and

24. Division of Hematology and Oncology, University of Nebraska Medical Center, Omaha, NE

Abstract

One-third of peripheral T-cell lymphomas are “not otherwise specified” (PTCL-NOS), but they have been subdivided into 2 subgroups based on gene expression profiling. Amador and colleagues generated an immunohistochemical algorithm that parallels the molecular separation of PTCL-NOS and provides useful prognostic information.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference42 articles.

1. Peripheral T-cell lymphoma (excluding anaplastic large-cell lymphoma): results from the Non-Hodgkin’s Lymphoma Classification Project;Rüdiger;Ann Oncol,2002

2. T-cell lymphomas in South America and Europe;Bellei;Rev Bras Hematol Hemoter,2012

3. WHO classification of tumours of haematopoietic and lymphoid tissues in 2008: an overview;Sabattini;Pathologica,2010

4. International peripheral T-cell and natural killer/T-cell lymphoma study: pathology findings and clinical outcomes;Vose;J Clin Oncol,2008

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