Antibody response after 2 and 3 doses of SARS-CoV-2 mRNA vaccine in allogeneic hematopoietic cell transplant recipients

Author:

Maillard Alexis1ORCID,Redjoul Rabah2,Klemencie Marion3,Labussière Wallet Hélène4,Le Bourgeois Amandine5,D'Aveni Maud6,Huynh Anne7ORCID,Berceanu Ana8,Marchand Tony9,Chantepie Sylvain10ORCID,Botella Garcia Carmen11,Loschi Michael12,Joris Magalie13,Castilla-Llorente Cristina14,Thiebaut-Bertrand Anne15,François Sylvie3,Leclerc Mathieu2,Chevallier Patrice16,Nguyen Stephanie1

Affiliation:

1. Department of Clinical Hematology, Hôpitaux Universitaires Pitié Salpêtrière, Paris, France;

2. Department of Clinical Hematology, Assistance Publique des Hôpitaux de Paris (APHP), Hôpital Henri Mondor, Créteil, France;

3. Department of Clinical Hematology, Angers University Hospital, Angers, France;

4. Department of Clinical Hematology, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Lyon, France;

5. Department of Clinical Hematology, Nantes University Hospital, Nantes, France;

6. Department of Hematology, Nancy Hospital, Nancy, France;

7. Department of Hematology, Institut Universitaire du Cancer Toulouse–Oncopole, Service de greffe de cellules souches hematopoïétiques, Toulouse, France;

8. Department of Clinical Hematology, Besançon University Hospital, Besançon, France;

9. Department of Clinical Hematology, Centre Hospitalier Universitaire (CHU) de Rennes, Rennes, France;

10. Institut d'Hématologie de Basse Normandie, Centre Hospitalier Universitaire de Caen, Caen;

11. Department of Hematology and Cell Therapy, CHU de Bordeaux, Bordeaux, France;

12. Department of Hematology, CHU de Nice, Université Cote d'Azur, Nice, France;

13. Department of Hematology, CHU Amiens, Amiens, France;

14. Institut de Cancérologie Gustave Roussy, Villejuif, France;

15. Department of Clinical Hematology, CHU de Grenoble, Grenoble, France; and

16. Department of Clinical Hematology, Nantes University Hospital, Nantes, France

Abstract

Three reports address the protection of the vulnerable population of patients with hematologic malignancies in the face of the ongoing COVID pandemic. The reports suggest that some patients who fail to mount a B-cell response to vaccine may nevertheless have protective T cell responses. As a group, these reports suggest that patients should continue to be immunized with additional doses to attempt to improve immune response but that they need to maintain the precautions recommended for the unvaccinated.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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